A two dimensional frame has been designed according to IS 800-2007 and are subjected to dead load, live load and earthquake load combination. In the present study reliability assessment of structural safety is studied. The uncertainties in geometry, loads and strength are accounted. The performance function for strength is studied using Hasofer Lind method. A MATLAB program has been developed for computing the reliability index for beams and columns. System reliability has been performed on the structure to find the reliability index of the system.